Join Secoya Technologies at CPHI Milan from October 8th to 10th.
Nandi, S. et al. Continuous Microfluidic Antisolvent Crystallization as a Bottom-Up Solution for the Development of Long-Acting Injectable Formulations. Pharmaceutics 2024, 16, 376. https://doi.org/10.3390/pharmaceutics16030376
A bottom-up approach was investigated to produce long-acting injectable (LAI) suspension-based formulations to overcome specific limitations of top-down manufacturing methods by tailoring drug characteristics while making the methods more sustainable and cost-efficient. A Secoya microfluidic crystallization technology-based continuous liquid antisolvent crystallization (SCT-CLASC) process was optimized and afterwards compared to an earlier developed microchannel reactor-based continuous liquid antisolvent crystallization (MCR-CLASC) setup, using itraconazole (ITZ) as the model drug. After operating parameter optimization and downstream processing (i.e., concentrating the suspensions), stable micro suspensions were generated with a final solid loading of 300 mg ITZ/g suspension. The optimized post-precipitation feed suspension consisted of 40 mg ITZ/g suspension with a drug-to-excipient ratio of 53:1. Compared to the MCR-CLASC setup, where the post-precipitation feed suspensions contained 10 mg ITZ/g suspension and had a drug-to-excipient ratio of 2:1, a higher drug concentration and lower excipient use were successfully achieved to produce LAI microsuspensions using the SCT-CLASC setup. To ensure stability during drug crystallization and storage, the suspensions’ quality was monitored for particle size distribution (PSD), solid-state form, and particle morphology. The PSD of the ITZ crystals in suspension was maintained within the target range of 1–10 m, while the crystals displayed an elongated plate-shaped morphology and the solid state was confirmed to be form I, which is the most thermodynamically stable form of ITZ. In conclusion, this work lays the foundation for the SCT-CLASC process as an energy-efficient, robust, and reproducible bottom-up approach for the manufacture of LAI microsuspensions using ITZ at an industrial scale.
This webinar introduces the latest advances in core-shell microcapsule technology. Discover how microcapsules are used as a versatile tool in drug delivery, encapsulation, crystallization, compound characterization, and more.
Explore the challenges of traditional microencapsulation methods and the transformative potential of microfluidic technology in producing precise, uniform microcapsules. Gain insights into the advantages of UV light crosslinking for rapid and solvent-free capsule production (Methacrylate-based resins, PEGDA, PEGDMA).
In the case study discussion of the program, a particular emphasis will be placed on the use of microcapsules for the screening of crystallization conditions.
Learn how to generate hundreds of identical UV-crosslinked microcapsules per second, produced by Secoya Technologies’ RayDrop and its all-in-one platform.
Speakers
Joseph Farah : Microfluidic Application Engineer·
Marie Mettler : R&D Engineer – Secoya Technologies
Adrien Dewandre : Technology Lead – Emulsification & Droplet generation – Secoya Technologies
Join us for the 3rd edition of the Flow Chemistry Pavilion at ACHEMA 2024!
The Flow Chemistry Pavilion brings together 25+ Companies working in the area of Flow Chemistry & gives visitors the opportunity to meet the Flow Community at a Global Tradeshow. Alongside the five-day exhibition will be a two-day Symposium, enabling visitors to learn what’s new in the area of Continuous Manufacturing.
Where to find us: hall 8 booth E64-020.
Secoya Technologies has confirmed its participation in the upcoming Formulation and Delivery Congress set to be held in London from April 26th to April 28th.
Meet Diala Youssevitch, Adrien Dewandre and Bart Rimez to discover our latest API encapsulation and crystallization improvements.
About Formulation and Delivery
Formulation & Delivery 2024 aims to connect pharmaceutical & biotech representatives as well as academia for high-level discussions on the latest innovations in pharmaceutical drugs formulation, drug delivery, inhaled therapeutics & RNA development.
This momentous achievement allows Secoya Technologies to explore and expand into new markets.
We are delighted to announce the completion of our fundraising for an amount of €1million.
Bertrand Loriers, CEO commented: “This is a new milestone for Secoya. It will allow us to move to a new level of growth while we have a better knowledge of our customers and potential markets. These resources will indeed be allocated in a relevant way to our commercial deployment and to the operational reinforcement required to support our development. We seize the opportunity to thank our shareholders for trusting us.”
With a board of industry veterans, including former Delphi Genetics CEO Cédric Szpirer, Univercells co-founder Jose Castillo, Jean-Marie Solvay, and Stéphanie Hoffmann-Gendebien, Secoya already counts several major pharma companies among its clients in Europe and is expanding to the US.
Read the full article (in French): https://www.lecho.be/entreprises/pharma-biotechnologie/secoya-revisite-les-procedes-de-production-en-biopharma/10448380.html
Secoya Technologies will participate at the next CPhI Summit in Milan from November 9 to 11, 2021. If you want to discover more about our technologies or see our products in real life, come and meet us at out booth 10K90 (Pavillon PMEC)!
If you would like to meet with one of our technology experts on site, do not hesitate to contact us at info@secoya.com.
Looking forward to meeting you!
Would you like to learn more about our innovative technologies? Join us at the CPhi Discover and come to our virtual booth for a discussion.
20/01/2021
Secoya Technologies will participate in the next CCP Summit from March 23 to 25, 2021. Bart Rimez, co-founder and Technology Lead, will give a presentation on the Secoya Crystallization technology.
Adrien Dewandre and Youen Vitry, Technology leads at Secoya, and Benoit Scheid, Chairman of the Board of Secoya and Maître de Recherche FNRS at ULB, were involved in an experimental and numerical study of the Secoya droplet generator, the Raydrop. Their work on “Microfluidic droplet generation in a non-embedded co-flow-focusing using 3D printed nozzle” is published in the journal Scientific Reports.
28/10/2020
On November 17rd at 5 pm, Youen Vitry, co-founder and Encapsulation Technology Lead, will give a Webinar in collaboration with Fluigent on the Raydrop technology for the generation of double emulsion.
Register to the webinar : https://www.fluigent.com/resources/webinars/
28/10/2020
On June 23rd, Adrien Dewandre, co-founder and Encapsulation Technology Lead, has given a Webinar in collaboration with Fluigent on the Raydrop technology for the droplet generation.
Access now to the replay : https://webikeo.com/webinar/raydrop-a-universal-droplet-generator-based-on-a-non-embedded-co-flow-focusing/replay
26/08/2020
Secoya Technologies will participate in the next CPHi Festival of Pharma from October 5 to 16, 2020. If you would like to know more about one of our technologies, do not hesitate to request a virtual meeting through the CPhI platform.
26/08/2020
Jean Septavaux, Technology lead at Secoya has been involved in the modelling of complex molecular systems with the CSAp lab from the University of Lyon. Their work on “The dark side of disulfide-based dynamic combinatorial chemistry” was published in the journal Chemical Science.
26/08/2020
Please find below the timeslots and links to which the Secoya webinar on our crystallization technology will be broadcasted at the Virtual Process Show.
The webinar describes in detail the principles and the unique benefits of this new crystallization technology. It includes also the presentation of the latest results on the technology.
11.09.2020 at 10:00 CET
11.09.2020 at 18:00 CET
12.09.2020 at 02:00 CET
Would you be interested in this new technology ? Please join us at one of the three webinar time slots.
03/06/2020
We are pleased to announce that Secoya Technologies has signed an important collaboration contract with a world top 5 pharmaceutical company. The collaboration focuses on the joint use of intensified chemical synthesis and pervaporation technologies developed by Secoya and aims to develop a prototype that fits into the client’s production process.
3/02/2020
Dr. Bart Rimez, co-founder and Crystallization Technology Lead, was invited to publish in the Emerging Scientists issue of Journal of Flow Chemistry, coming out beginning 2020. The paper deals with our findings on the synergistic effect of nucleation thermodynamics and hydrodynamics to increase nucleation rate. Read more
29/01/2020
Dr Rimez, co-founder and Crystallisation Technology Lead, will be present at the forthcoming conference, Flow Chemistry Europe 2020, 3-4 March 2020, Cambridge (UK). Dr Rimez will give a lecture on the development of capillary crystallisation reactors.
28/01/2020
On 28Th January 2020, Fluigent and Secoya Technologies signed an exclusive distribution agreement under which Fluigent is responsible for the marketing and the sales of the RayDrop®, an innovative technology of Secoya dedicated to the production of droplets or particles for multiple applications. More information on the RayDrop on www.fluigent.com.
13/01/2020
Would it be possible to valorise a waste stream… by purifying another ? Dr. Jean Septavaux, co-founder of Secoya Technologies, co-authored a paper in Nature Chemistry describing a methodology for the convergent purification of electronic and gas waste streams. By using the unique properties of polyamines solutions upon capture of CO2 from car exhaust fumes, the authors manage to separate with a high selectivity the valuables metals contained in a dissolved car battery electrode.