Categories for Crystallization

WEBINAR: Transforming your crystallization process

Screening crystallization parameters for targeted particle size distribution might be challenging and time-consuming.

Join this webinar to discover how Secoya’s Crystallization Technology transforms the process with spontaneous nucleation, making it faster and more efficient. During this LIVE session, the setup of the instrument will be shown for both cooling and antisolvent crystallization. At the end of this webinar, Bart Rimez our technology lead will explain the overall philosophy of Secoya.

Book your seat and learn how the SCT technology can be extrapolated to other molecules, how to obtain the required particle size distribution with the setup of experimental designs and how to upscale it using the SCT-PILOT unit.

Speakers

Bart Rimez, Secoya Co-Founder and Crystallization Tech Leader

THIS WEBINAR HAS ALREADY TAKEN PLACE

If you couldn’t join us for our live webinar “Transforming your crystallization process” or if you just want to experience it again, you can watch it again!

PUBLICATION: Continuous Microfluidic Antisolvent Crystallization as a Bottom-Up Solution for the Development of Long-Acting Injectable Formulations

Nandi, S. et al. Continuous Microfluidic Antisolvent Crystallization as a Bottom-Up Solution for the Development of Long-Acting Injectable Formulations. Pharmaceutics 2024, 16, 376. https://doi.org/10.3390/pharmaceutics16030376

Abstract

A bottom-up approach was investigated to produce long-acting injectable (LAI) suspension-based formulations to overcome specific limitations of top-down manufacturing methods by tailoring drug characteristics while making the methods more sustainable and cost-efficient. A Secoya microfluidic crystallization technology-based continuous liquid antisolvent crystallization (SCT-CLASC) process was optimized and afterwards compared to an earlier developed microchannel reactor-based continuous liquid antisolvent crystallization (MCR-CLASC) setup, using itraconazole (ITZ) as the model drug. After operating parameter optimization and downstream processing (i.e., concentrating the suspensions), stable micro suspensions were generated with a final solid loading of 300 mg ITZ/g suspension. The optimized post-precipitation feed suspension consisted of 40 mg ITZ/g suspension with a drug-to-excipient ratio of 53:1. Compared to the MCR-CLASC setup, where the post-precipitation feed suspensions contained 10 mg ITZ/g suspension and had a drug-to-excipient ratio of 2:1, a higher drug concentration and lower excipient use were successfully achieved to produce LAI microsuspensions using the SCT-CLASC setup. To ensure stability during drug crystallization and storage, the suspensions’ quality was monitored for particle size distribution (PSD), solid-state form, and particle morphology. The PSD of the ITZ crystals in suspension was maintained within the target range of 1–10  m, while the crystals displayed an elongated plate-shaped morphology and the solid state was confirmed to be form I, which is the most thermodynamically stable form of ITZ. In conclusion, this work lays the foundation for the SCT-CLASC process as an energy-efficient, robust, and reproducible bottom-up approach for the manufacture of LAI microsuspensions using ITZ at an industrial scale.

Read more

Secoya at Formulation & Delivery to present Crystallization and Encapsulation technologies

Secoya Technologies has confirmed its participation in the upcoming Formulation and Delivery Congress set to be held in London from April 26th to April 28th.

Meet Diala Youssevitch, Adrien Dewandre and Bart Rimez to discover our latest API encapsulation and crystallization improvements.

About Formulation and Delivery

Formulation & Delivery 2024 aims to connect pharmaceutical & biotech representatives as well as academia for high-level discussions on the latest innovations in pharmaceutical drugs formulation, drug delivery, inhaled therapeutics & RNA development.

Read more

 

ACS publication: Parameter Optimization from Laboratory- to Kilogram Pilot-Scale Operations in Crystallization

BREAKING NEWS! Our recent work on the continuous nucleation process of lactose and adipic acid has been published on the American Chemical Society website.

Read our publication (https://doi.org/10.1021/acs.oprd.3c00132) to discover how Secoya Crystallization Technology (SCT) and its equipment allow crystallization experts to obtain a set of optimal parameters from a small amount of material to be used seamlessly at a pilot scale. A scalable process enabling full continuous production of nucleated slurry.

Congratulations to Bart Rimez
, Benoit Scheid
and Robin Debuysschère (Université libre de Bruxelles) for achieving this!

CRYSTA’DAYS – Two-day Crystallization dedicated event hosted by Secoya Technologies

In November 2023, a two-day event orchestrated by Secoya gathered a community of experts in crystallization in Louvain-La-Neuve. During these two dedicated days technology leads, esteemed researchers and academics showcased their groundbreaking work captivating an audience of industry experts coming from all around Europe.

 
Title
Speaker
From microfluidics at TIPs to Secoya
Prof. Benoit Scheid (ULB)
Introduction to Secoya crystallization technologies and crystallization
The theoretical and mathematical description of nucleation in shear flow conditions
Prof. Alessio Zaccone
The nucleation of molecules in solution using shear flow
Robin Debuysschère
API crystallization with Secoya Technology
Erik ter Voert
Introduction to the new SCT-LAB instrument
Dr. Bart Rimez
Filtration by DrM, Dr. Müller AG
Patrick Morsch
High throughput single crystal formation in core-shell capsules
Marie Mettler
From lab to pilot to scale-up ICE version: translation of conditions + case studies
Bart Rimez

Complete the form to unlock access to all the presentations!

BREAKING NEWS: Secoya Technologies and ULB achieved a patent milestone in India.

 This momentous achievement allows Secoya Technologies to explore and expand into new markets.

NEW Application Note: A quick and efficient double emulsion generation method for flow cytometry droplet sorting

In this paper, we describe the encapsulation of a fluorescent strain of Escherichia coli bacteria in w/o/w double emulsions and flow cytometry droplet sorting using a flow cytometry cell sorter (also commonly known as FACS). The Secoya’s RayDrop platform (including the RayDrop® device and distributed by Fluigent) allows the bacteria to be compartmentalized within a protective shell and ensures compatibility with the sorting device. The platform generates double emulsions in one step, scaling the production of common two-step double emulsion generation methods by up to ten times. Several hundred microliters of emulsions can be produced in 30 minutes, and multiple conditions can be tested within a single day, compared to a week with traditional methods. In addition, the platform integrates fluidic, pneumatic, and optic solutions, and does not require complex fabrication steps nor surface treatment. This application note was written in collaboration with Delphine Lestrade (head of the flow cytometry platform at Toulouse White Biotechnology, TWB) and Sophie Lajus (researcher at the Toulouse Biotechnology Institute, TBI)

WEBINAR: Upscaling of the crystallization process towards a full continuous crystal production

About this Webinar:

During this webinar, Bart Rimez our expert in Crystallization, demonstrated how the Secoya Crystallization Technology (SCT) process can be seamlessly scaled up from laboratory to production scale by tightly controlling various parameters.

At the laboratory scale, a set of parameters is identified and enables the production of the desired particle sizes and distributions. This same set of parameters can then be directly transferred to pilot-scale or production-scale processes, thus providing a reliable and efficient means of scaling up the SCT process.

Speakers:

 

Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies
Diala Youssevitch | Technical Sales Manager

Invited speaker: Jan Vogeleer | Managing Director, Fette Compacting

NEW White paper: The upscaling of lactose crystallization towards a full continuous crystal production

 

This white paper offers valuable insights into the upscaling of lactose crystallization for achieving fully continuous crystal production. By downloading it, you’ll discover how to optimize the parameters at the lab scale, enabling labs to achieve consistent results in terms of particle size and distribution at the pilot and even production scale when reactors are placed in parallel.

Secoya will be attending Formulation & Delivery 2023 (25 – 26 May) | London, UK to present Crystallization Technology

Our particle engineering experts will be in London end of May with other leading experts in pharmaceutical science to present Secoya’s Crystallization Technology (SCT) during the Formulation and Delivery addressing the critical strategic advances and technical innovation in formulation, drug delivery and drug product development. Also, attending the Formulation and Delivery Congress? Stop by our booth (#17) to discover our unique technology that enables a fast and easy scale-up of the crystallization process thanks to tight control of specific parameters such as particle size or distribution and that remain the same from lab to production scale.

 
 

SCT Family: equipments from lab to industrial scale

 

From the laboratory setup to the industrial-scale equipment, Secoya Technology has developed a full range of products that use the same parameters set all along the scale-up process:

SCT-LAB

This bench equipment has everything to make your life easy for fast crystallization screening. The batch type approach allows fast screening whilst assuring low product consumption.

Discover the SCT-LAB

SCT-PILOT

SCT-PILOT unit allows to fully explore the design space of a crystallization process, performing controlled long-term runs on one single reactor on the same experimental conditions as the SCT-LAB equipment.

Discover SCT-PILOT

SCT-ICE

The cGMP SCT-ICE unit is designed for easy access and exchange of modules, depending on the customers needs. Versatile, it enables the production of different compounds by simply exchanging the modules in between production runs.

Discover the SCT-ICE

About the Secoya Crystallization Technology:

 

Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.

Secoya’s crystallization technology is unique, enabling crystallization of molecules in a single process step avoiding difficult work-up when performed with conventional batch systems.

WEBINAR: SCT-LAB laboratory setup (LIVE DEMO), the first step to optimize your crystallization process

 

About this Webinar:

This webinar aims to present the SCT-LAB laboratory setup which has everything to ease the fast crystallization screening. Indeed, using the SCT-LAB allows the study of correct polymorph nucleation, operational zonewidth determination, test reproducibility and influence of parameter variability, robustness of ruling conditions, yield, and many more.

DATE: Wednesday May 25th
TIME: 5 pm CET

Speakers:

 

Bart Rimez, PhD | Co-owner And Technology Lead at Secoya Technologies
Bertrand Loriers | CEO at Secoya Technologies

 

During this Webinar you will discover…

– How easy is the SCT-LAB setup

The SCT-LAB setup is fast, simple and fits in all classic fume hoods, isolators, confined spaces, and so on. Inter-test cleaning of the reactor setup is easy and straightforward. Different types of mixers exist for cooling and antisolvent crystallization experiments.

– How you can optimize and control the nucleation by using the SCT-LAB

Unlike any alternative process, the Secoya crystallization technology is based on the precise control of spontaneous nucleation through the use of millifluidic tubular reactors upon cooling and different antisolvent addition possibilities. Using such capillaries, any parameter influencing the nucleation is ideally optimized and controlled.

 

The SCT approach to crystallization

In a White Paper we described earlier what the advantages of the use of Secoya’s Crystallization Technology (SCT) are to tame the nucleation of a material in solution inside a crystallization reactor as designed by Secoya [1]. Several advantages do exist: control of final crystal size, correct crystal form, inherent narrow size distributions, etc. But how exactly do you start using the technology, and how long does it take to develop a crystallization routine using the SCT technology?

Download our pdf

  [1] Find this white paper at: /documents/crystallization/

Hydrodynamics matters to control the crystallization of API

3/02/2020

Dr. Bart Rimez, co-founder and Crystallization Technology Lead, was invited to publish in the Emerging Scientists issue of Journal of Flow Chemistry, coming out beginning 2020. The paper deals with our findings on the synergistic effect of nucleation thermodynamics and hydrodynamics to increase nucleation rate. Read more